Feline Immunodeficiency Virus (FIV) in Cats: Causes, Symptoms, Care, and Prevention

Spotting health shifts early and boosting your companion’s well-being indoors.

By Shinta
Created on

Understanding Feline Immunodeficiency Virus (FIV) in Cats

Feline Immunodeficiency Virus, commonly known as FIV, is a chronic viral infection found in cats that undermines and weakens the immune system. FIV is often compared to human HIV, though it is species-specific and cannot be transmitted to humans or other animals. Managing FIV requires knowledge about symptoms, how it spreads, diagnosis, and the best practices for caring for an FIV-positive cat.

What Is FIV?

FIV is a retrovirus infection that primarily targets the white blood cells in a cat’s immune system, progressively diminishing the cat’s ability to fight off other diseases and infections. Discovered in the United States in the late 1980s, FIV belongs to the lentivirus subgroup of retroviruses, which means it typically causes slow-progressing diseases in cats.

  • Not contagious to humans or dogs
  • Almost always a life-long infection; there is no cure
  • Can remain dormant in a cat’s system for years before symptoms arise
  • Related to human HIV in structure and effect, but unique to felines

How FIV Affects Cats

FIV works by invading and damaging the cat’s immune system, leaving it vulnerable to infections it could ordinarily resist. Infected cats may spend years in apparent good health before showing any outward signs.

Phases of FIV Infection

PhaseMain Characteristics
Acute PhaseFever, depression, enlarged lymph nodes, lack of appetite lasting a few weeks—often mild and overlooked
Asymptomatic PhaseNo obvious symptoms, virus replicates slowly in immune cells; period may last months to years
Progressive (Immunocompromised) PhaseSecondary infections, chronic illness, oral inflammation, or cancer may develop; overall health declines

Common Symptoms of FIV in Cats

Symptoms of FIV may not appear for years, and when they do, they commonly include recurring health issues.

  • Poor coat condition
  • Chronic or recurrent fever
  • Lack of appetite (anorexia)
  • Enlarged lymph nodes (glands)
  • Inflammation or infection of gums and mouth (gingivitis and stomatitis)
  • Persistent or recurring infections (eyes, skin, urinary tract, respiratory tract, bladder)
  • Diarrhea
  • Weight loss (often slow and progressive)
  • Eye problems
  • Neurological signs: seizures, behavioral changes, balance issues
  • Cancers, immune-mediated blood disorders
  • Lethargy/tiredness
  • Chronic skin diseases

Some cats do not show symptoms for a long time, which is why regular veterinary checkups are crucial.

How Does FIV Spread?

FIV transmission mainly occurs through deep bite wounds, which inject virus-rich saliva directly into the bloodstream. This occurs most commonly during fights between unneutered male cats.

  • Rarely spreads through casual contact (mutual grooming, shared bowls)
  • Can be transmitted from a pregnant queen to her kittens
  • May spread via blood transfusions
  • Does not survive long in the environment; easily killed by disinfectants

FIV is not spread via air, litter boxes, food bowls, or gentle social interactions unless a fight results in a bite.

Risk Factors for Infection

  • Outdoor cats—higher risk due to exposure to other cats
  • Unneutered male cats—much more likely to fight
  • Free-roaming or feral cat populations
  • Multi-cat households with aggressive behavior

Diagnosing FIV in Cats

FIV diagnosis is based on blood tests that detect virus-specific antibodies. Early in the infection, a cat may test negative before antibodies develop.

  • ELISA (Enzyme-Linked Immunosorbent Assay)—the most common initial screening test
  • Western Blot or PCR—confirmatory tests for ambiguous or positive results
  • Repeat testing suggested for kittens under six months old, as maternal antibodies may interfere
  • Regular check-ups: blood work may reveal reduced white blood cell count and other abnormalities

Discuss positive results with your veterinarian to plan your cat’s care and to minimize transmission risk to other cats.

Prognosis and Living with FIV

The prognosis for FIV-positive cats has improved significantly; many live long, healthy lives, especially if kept indoors and provided proper veterinary care.

  • Asymptomatic period may last several years
  • Quality of life can remain high with regular medical oversight and prompt infection management
  • Some FIV-infected cats never develop life-threatening problems
  • Others may eventually suffer severe secondary infections or cancer

Euthanasia is generally not recommended unless advanced stages of disease seriously compromise quality of life.

Treatment and Management of FIV

There is no cure for FIV, but supportive care and routine veterinary attention significantly improve prognosis.

General Principles of FIV Management

  • Neuter or spay infected cats—minimizes risk of fights and transmission
  • Keep FIV-positive cats indoors—protects them from exposure to pathogens and prevents FIV spread to other cats
  • Feed a high-quality, commercial diet—avoid raw foods due to risk of foodborne infection
  • Routine parasite control—reduces burden of other illnesses
  • Prompt and aggressive treatment of all infections—antibiotics are often effective but infections may recur
  • Regular veterinary monitoring: at least twice yearly exams including blood and urine testing
  • Consult with your veterinarian about appropriate vaccines; recommendations vary by location and risk factors

Medications

  • Antibiotics—for secondary bacterial infections
  • Antioxidants and immune-boosting drugs—may provide supportive benefit
  • Human HIV drugs (e.g., AZT/zidovudine)—sometimes used for severe dental inflammation or neurologic disease

These treatments manage symptoms and complications rather than eliminating the virus.

Prevention of FIV

Strategies focus on minimizing the risk of exposure and transmission.

  • Keep cats indoors or supervised outdoors
  • Neuter male cats—reduces aggressive behavior
  • Test new cats before introducing them to multi-cat households
  • Avoid fights and contact with stray or feral cats
  • Maintain a clean environment—virus is easily killed by routine cleaning and disinfectants

There used to be a vaccine for FIV, but it is no longer widely available and is not considered very effective due to viral diversity. Always consult your veterinarian for up-to-date advice regarding prevention.

Providing the Best Care for FIV-Positive Cats

Caring for an FIV-positive cat involves a combination of medical, environmental, and dietary practices.

  • Observe your cat closely for any changes in behavior, appetite, or health
  • Schedule regular veterinary visits for ongoing assessment
  • Immediate attention to any symptoms, infections, or illness
  • Keep stress minimized for your cat to reduce immune system burden
  • Avoid feeding raw or undercooked foods—dangerous pathogens
  • Do not use immunosuppressive drugs unless specifically prescribed by a veterinarian

Most FIV-positive cats do not require special diets or supplements unless recommended by your vet due to concurrent health conditions.

Frequently Asked Questions About FIV in Cats

Q: Can FIV be transmitted to humans or dogs?

A: No, FIV is specific to cats and cannot infect humans or other species.

Q: How long can a cat live with FIV?

A: Many cats live for years without significant problems, especially with good veterinary care and a healthy lifestyle.

Q: Should FIV-positive cats be euthanized?

A: Euthanasia is not necessary unless multiple severe illnesses or infections occur that cannot be managed and quality of life is poor.

Q: Is there any treatment to cure FIV?

A: No cure exists, but symptoms and secondary infections can be treated; maintaining good overall health is the best strategy.

Q: Will my FIV-positive cat infect other cats in the household?

A: Transmission risk is low in non-aggressive multi-cat households; most infections require a deep bite wound.

FIV vs. FeLV: What’s the Difference?

FeatureFIVFeLV
Virus FamilyRetrovirus (Lentivirus)Retrovirus (Oncornavirus)
TransmissionBitingSaliva, close contact, grooming, bites, food bowls
SymptomsImmune suppression, oral disease, slow progression, chronic infectionsImmune suppression, anemia, cancers, often rapid progression
PrognosisLong asymptomatic period possibleShorter survival after infection

Though both are retroviruses that cause immune system damage and similar symptoms, their transmission methods and long-term effects differ significantly.

Key Takeaways for Cat Owners

  • Regular veterinary care and early detection improve FIV-positive cats’ quality of life
  • Indoor living is safest for infected cats and others in the community
  • Prompt attention to infections and health concerns is critical
  • With proper care, many FIV-positive cats enjoy a normal lifespan
  • Consult your veterinarian for individualized management and for introducing new cats to your household

References (For Additional Reading)

  • WebMD: Cats and FIV: Symptoms, Causes, and Treatments
  • International Cat Care: Feline Immunodeficiency Virus (FIV)
  • Cornell Feline Health Center: Feline Immunodeficiency Virus (FIV)
  • VCA Hospitals: Feline Immunodeficiency Virus Infection
  • Zoetis Petcare: Caring for a FIV Positive Cat
Shinta is a biotechnologist turned writer. She holds a master's degree in Biotechnology from Karunya Institute of Technology and Sciences and a PG Diploma in cellular and molecular diagnostics from Manipal University. Shinta realised her love for content while working as an editor for a scientific journal.

Read full bio of Shinta