Appetite Stimulants For Cats: A Complete Guide To Boost Eating

Discover proven veterinary and home methods to restore your feline’s healthy hunger.

By Shinta
Created on

Appetite Stimulants for Cats: Helping Your Cat Eat Better

Cats can be notoriously finicky eaters—but when your cat won’t eat at all, it can signal a serious health risk and deep worry for pet parents. Loss of appetite (anorexia) in cats is often more than just fussiness; it can be a sign of an underlying medical condition or stress response. Fortunately, veterinarians have a variety of appetite stimulants to help cats start eating again, ranging from prescription medications to supportive home strategies. This guide explores the best appetite stimulants for cats, how they work, possible side effects, and what every cat owner should know before starting treatment.

When Do Cats Need Appetite Stimulants?

It’s normal for cats to skip a meal now and then. But when a cat refuses to eat for more than 24 hours, it is a cause for concern and should never be ignored. Extended inappetence can quickly lead to hepatic lipidosis (also known as “fatty liver syndrome”), a life-threatening condition unique to felines. Here are some common reasons why a cat might lose its appetite:

  • Chronic illnesses, such as chronic kidney disease, hyperthyroidism, or gastrointestinal issues
  • Pain or discomfort, including dental disease or injury
  • Stress, changes in the home environment, or introduction of new pets
  • Side effects from medication or treatments, such as chemotherapy
  • Age-related changes, including reduced sense of smell or taste

If your cat consistently refuses food for more than a day, it’s vital to consult a veterinarian. Never attempt to force-feed or give medications without professional guidance.

Prescription Appetite Stimulants for Cats

When behavioral modifications and environmental adjustments aren’t enough, veterinarians may prescribe specific medications to increase appetite in cats. Major options include:

Best Overall Prescription Appetite Stimulant: Mirataz (Mirtazapine Transdermal Ointment)

Mirataz contains mirtazapine, a medication initially developed as an antidepressant in humans. It’s now widely used as an appetite stimulant for cats due to its dual ability to reduce nausea and boost hunger. Mirataz has been FDA-approved specifically for feline appetite stimulation and is regarded as a first-line treatment by many veterinarians.

  • Applied externally via a 1.5-inch strip of ointment to the cat’s inner ear once daily
  • Each Mirataz package contains a 14-day supply
  • Particularly helpful for cats who resist pills or liquids
  • Prescription-only medication

Potential Side Effects & Cautions:

  • Drowsiness is the most common side effect
  • May rarely cause “serotonin syndrome,” which includes agitation and muscle tremors
  • Less commonly, changes in bone marrow or blood cell counts
  • Should be used with caution in cats with liver or kidney issues or blood disorders (such as feline leukemia)
  • Possible interactions with other drugs, including MAOIs and SSRIs

Mirtazapine (Tablet or Liquid Form)

Mirtazapine is also available in pill or liquid form, providing the same appetite-boosting and anti-nausea effects. However, for cats that refuse oral medication, the transdermal ointment (Mirataz) is often preferred for ease of application and improved compliance.

Key notes:

  • Tablets or liquids must be administered by mouth at dosages determined by your veterinarian
  • Can cause drowsiness or behavioral changes
  • Monitor for interactions with other medications

Capromorelin (Elura)

Capromorelin (brand name Elura) is a relatively new appetite stimulant approved for use in cats with chronic kidney disease. This medication works by mimicking ghrelin, a hormone that triggers hunger signals in the brain and digestive tract.

  • Administered as a flavored oral liquid, once daily
  • Especially effective for cats with kidney conditions
  • Prescription required

Common side effects: vomiting, drooling (hypersalivation), tiredness, mild dehydration.

Cyproheptadine

Cyproheptadine is an antihistamine and serotonin antagonist that can increase appetite by blocking serotonin’s natural appetite-suppressing effects in the brain. It is not FDA-approved for use in cats but is commonly prescribed “off-label” by veterinarians.

  • Administered as tablets, typically 1–2 mg once or twice daily
  • Well-tolerated by many cats, though mild sedation or dry mouth can occur
  • Not to be used simultaneously with mirtazapine, due to additive sedative effects

Oxazepam

Oxazepam is a benzodiazepine that works by enhancing the appeal of food in a cat’s brain. Reserved for short-term use or for acutely stressed, hospitalized cats, oxazepam is usually not recommended for chronic appetite issues.

  • Given orally at a dose set by your veterinarian, typically 2 mg per cat every 12-24 hours
  • Causes sedation — making it more suitable for brief use rather than as an ongoing solution
  • Should not be combined with other sedating medications

Diazepam

Diazepam, another benzodiazepine, can stimulate appetite when given intravenously (IV). Cats often start eating within minutes of injection. Note: Oral diazepam should be used cautiously due to risk of dangerous liver toxicity.

  • Intravenous use only, for short-term stimulation in a clinical setting
  • High risk if given by mouth: associated with liver failure in cats, so regular bloodwork and veterinary supervision are essential

How We Chose the Top Appetite Stimulants

The appetite stimulants featured here were selected based on:

  • Effectiveness and reliability (supported by clinical research and veterinary experience)
  • Reviews from cat owners and feedback from veterinary professionals
  • Side effect profile and tolerability
  • Available forms (ointment, oral, liquid, tablet)
  • Suitability for picky or medication-averse cats

We also factored in the practical experiences of cat guardians, for whom ease of administration is crucial—cats who won’t eat are rarely easy medicine takers!

Other Medical Approaches and Considerations

While the medications above are the most commonly prescribed appetite stimulants, other medical options might be considered for specific cases. These include:

  • Corticosteroids (e.g., prednisolone): Sometimes used for appetite stimulation, but only in select cases due to potential side effects
  • B Vitamins and Nutritional Supplements: May assist with appetite in cats who have vitamin deficiencies or are recovering from illness
  • Electrolyte supplements: Indirectly improve appetite by maintaining hydration and cellular function

Always consult your veterinarian before introducing any new medications or supplements. Regular monitoring and communication with your vet are essential to prevent adverse reactions.

Natural and Home Strategies to Boost Cat Appetite

Not every case of poor appetite requires pharmaceuticals. A few home-care and environmental adjustments can make a big difference for mildly inappetent or recovering cats:

  • Warming Food: Slightly warming wet food (not hot!) can enhance aroma and appeal
  • Switching Flavors or Textures: Different brands, proteins, or consistencies may tempt your cat
  • Offering Small, Frequent Meals: Encourages regular eating and reduces mealtime pressure
  • Hand-Feeding: For social eaters, feeding directly from your hand can provide comfort
  • Minimizing Stress: Reducing noise, creating a cozy eating space, and minimizing other household changes can help nervous cats eat again
  • Using Fishy Treats: A few pieces of cooked salmon or tuna water (not oil or salted) might spark interest
  • Hydration: Some cats benefit from an added cat-safe broth or watered-down food

Never use over-the-counter human appetite stimulants, herbs, or essential oils without veterinary approval—some can be toxic to cats.

What to Watch For: Risks and Side Effects

As with any medication, side effects are possible with feline appetite stimulants. The most common issues include:

  • Drowsiness or lethargy
  • Drooling or increased salivation
  • Gastrointestinal upset (vomiting or diarrhea)
  • Changes in behavior (restlessness, agitation)
  • Increased thirst or urination
  • Rarely, more serious reactions such as blood disorders (with mirtazapine) or hepatotoxicity (with oral diazepam)

Always monitor your cat’s response to new medications closely and report any unusual signs to your veterinarian immediately.

Frequently Asked Questions (FAQs)

How long can a cat safely go without eating?

Most healthy adult cats should not go more than 24 hours without food. Kittens, sick, or senior cats are even more vulnerable to the dangers of anorexia and require faster intervention.

How quickly do appetite stimulants work in cats?

This depends on the medication. IV diazepam can work in minutes; mirtazapine or Mirataz typically begins to take effect in a few hours, while cyproheptadine and capromorelin may take a day or more. Always follow your vet’s dosage and timing instructions.

Are there any safe over-the-counter appetite stimulants for cats?

No non-prescription drugs or supplements are approved as appetite stimulants for cats. Attempts with herbs or human medications can be very dangerous; always consult a veterinarian before trying any OTC product.

Can I use human appetite stimulants for my cat?

Never use human appetite stimulants in cats unless specifically prescribed by your veterinarian. Many are unsafe or lethal for cats.

What should I do if my cat’s appetite doesn’t improve, even with medication?

Contact your veterinarian promptly. Persistent anorexia may signal a deeper health problem or require adjustment in treatment or supportive care.

Key Takeaways: Supporting Your Cat’s Recovery

  • Loss of appetite in cats can be a serious medical emergency, not just a behavioral quirk
  • Prescription appetite stimulants—like Mirataz (mirtazapine), capromorelin, cyproheptadine, and oxazepam—are effective options, but each comes with specific uses and side effects
  • Supportive home care, environmental modifications, and gentle encouragement can also play a vital role in restoring your cat’s appetite
  • Always consult your veterinarian before starting any appetite stimulant or making major dietary changes
  • Careful monitoring, patience, and compassion are key during your cat’s recovery

Additional Resources and Professional Support

If you’re concerned about your cat’s appetite or have questions about the best way to help them eat, consult your veterinarian as soon as possible. Expert medical advice and tailored treatment plans provide the safest path to helping your cat regain a healthy appetite and quality of life. Regular check-ins, bloodwork, and open communication can make all the difference in delicate or chronic cases.

Shinta is a biotechnologist turned writer. She holds a master's degree in Biotechnology from Karunya Institute of Technology and Sciences and a PG Diploma in cellular and molecular diagnostics from Manipal University. Shinta realised her love for content while working as an editor for a scientific journal.

Read full bio of Shinta