DGL for Acid Reflux: Uses, Benefits, Side Effects, and FAQs

Explore how DGL (deglycyrrhizinated licorice) may help acid reflux, along with its benefits, safety, and best practices for supplementation.

By Medha deb

Created on Sep 26, 2025

Explore how DGL (deglycyrrhizinated licorice) may help acid reflux, along with its benefits, safety, and best practices for supplementation.

DGL for Acid Reflux: Uses, Benefits, Safety, and Frequently Asked Questions

Acid reflux is a common digestive complaint that can cause significant discomfort and disrupt daily life. While prescription and over-the-counter antacids remain first-line solutions for many, interest in natural remedies is growing. Among these, DGL (deglycyrrhizinated licorice) has become a popular supplement purported to help soothe the digestive tract and potentially relieve symptoms of acid reflux and GERD (gastroesophageal reflux disease). This article explores the science behind DGL, its effectiveness, how it works, usage tips, safety concerns, potential side effects, and alternatives.

What Is DGL?

DGL stands for deglycyrrhizinated licorice, a form of licorice root extract that has had the glycyrrhizin removed. Glycyrrhizin is a compound in natural licorice known for its potential to cause serious side effects, such as elevated blood pressure and low potassium levels, when consumed in large amounts over time. By removing glycyrrhizin, DGL retains many of licorice’s reputed health-supporting properties (especially for the digestive tract) while minimizing the risk of serious adverse effects related to glycyrrhizin exposure.

Licorice root has traditionally been used for a range of issues, including gut and throat problems, hormonal imbalance, and respiratory support.
DGL is widely available as supplements, particularly chewable tablets and gummies.

How Does Acid Reflux Occur?

Acid reflux or heartburn occurs when stomach acid flows backward into the esophagus, often due to a weakened or malfunctioning lower esophageal sphincter (LES) valve. When the LES cannot close properly, stomach acid irritates the delicate lining of the esophagus, resulting in a burning sensation, pain in the chest, burping, sore throat, and sometimes chronic cough.

Chronic acid reflux is officially called GERD (gastroesophageal reflux disease).
Common triggers include certain foods, obesity, smoking, stress, and hiatal hernia.

How Might DGL Help with Acid Reflux?

The main theory behind DGL’s benefits for acid reflux is its dual action:

Protecting and repairing mucosa: DGL is believed to stimulate mucus production and increase blood flow to the esophageal and stomach lining. Mucosa is a soft tissue layer that lines the digestive tract and protects against acid damage.
Reducing inflammation: DGL’s anti-inflammatory and antioxidant effects may help heal damage and reduce pain.
Soothing the digestive tract: DGL acts as an antispasmodic, relaxing smooth muscle in the gut and reducing discomfort related to acid reflux and indigestion.

By strengthening mucous membranes and increasing their resilience to acid, DGL may offer an additional layer of protection for people susceptible to acid reflux. Some research also suggests it can inhibit growth of H. pylori bacteria, linked to both ulcers and some cases of GERD.

The Science Behind DGL for Acid Reflux

A 2017 study found that a formula containing DGL improved GERD symptoms in a group of 58 participants over a two-year self-reporting period, though the research was limited in size and did not directly compare DGL versus placebo or DGL alone.
A 2018 observational study found DGL more effective than some over-the-counter acid-suppressive medication for digestive discomfort, but more research with robust controls is needed.
DGL is also supported for use in other irritation or inflammation of the digestive tract – such as gastric and intestinal ulcers or oral mucositis.

Important: Overall, clinical evidence is limited and not conclusive. More research is needed to determine doses, duration, and direct benefits in diverse populations.

Potential Benefits of DGL

Strengthens and repairs the gut lining by boosting mucus production and cell growth.
May accelerate healing of ulcers or erosions in the esophagus, stomach, or intestines.
May reduce side effects of some cancer treatments, such as oral mucositis.
May improve antioxidant defenses and reduce oxidative damage (seen in some animal studies).
Might help with symptoms of IBS (Irritable Bowel Syndrome) due to its soothing, demulcent effect.

How to Use DGL for Acid Reflux

DGL supplements come in various forms and strengths, but chewable tablets and gummies are preferred for acid reflux because mixing the supplement with saliva helps activate its protective compounds.

Chew thoroughly and allow DGL to mix with saliva. This may stimulate mucosal cell growth and maximize its efficacy for the throat and esophagus.
Capsules are less effective for reflux, as the product does not linger in the mouth and esophagus.
The usual recommendation: Take DGL 20 minutes before meals, especially before dinner, to maximize its protective effect.
Duration of use: DGL can be used for 2–4 months, followed by a break. Consult a healthcare professional for personal recommendations.

As with any supplement, discuss with your doctor, especially if you have any health conditions or are pregnant, breastfeeding, or taking other medications.

Sample Table: DGL Supplement Usage Overview

Form	When to Take	Recommended Action
Chewable tablet	20 min before meals	Chew thoroughly, mix with saliva
Gummy	20 min before meals	Let dissolve in mouth
Capsule	N/A for reflux	Not as effective; not recommended for reflux

Is DGL Safe? Possible Side Effects & Precautions

By removing glycyrrhizin, DGL significantly reduces the risk of serious side effects like high blood pressure, water retention, and low potassium levels associated with whole licorice root. Nonetheless, DGL is not completely free of risks.

DGL is generally considered safe when used for short periods as directed.
Rare side effects may include digestive upset (such as bloating or loose stools) or mild allergic reactions.
Individuals with severe liver or kidney disease, chronic high blood pressure, or hormonal disorders should use with caution and only under medical supervision.
Pregnant or breastfeeding women should avoid DGL unless directed otherwise by a healthcare provider.

Because DGL can still have hormonal actions and may interact with other medications, always consult your doctor before starting a new supplement regimen.

DGL vs. Medications and Alternative Treatments

Standard medical treatments for acid reflux and GERD include:

Over-the-counter antacids (such as calcium carbonate, magnesium/aluminum hydroxide)
H2 blockers (such as famotidine)
Proton pump inhibitors (PPIs) (such as omeprazole, lansoprazole)

These medications work primarily by reducing stomach acid production, directly neutralizing acid, or strengthening the LES over time.

While generally highly effective, long-term use of PPIs and H2 blockers may cause nutrient deficiencies or increase risk for infections.
DGL does not reduce acid directly, but strengthens mucosal defense and healing.
Lifestyle changes—such as weight management, reducing trigger foods, quitting smoking, and elevating the head of the bed—are also important for managing GERD symptoms.

What Does the Evidence Say About DGL?

Scientific support for DGL’s use in acid reflux is promising but still not conclusive:

Some small studies and user reports cite improvements in symptoms, particularly for mild or moderate reflux.
No large-scale, long-term trials have definitively proven effectiveness (or optimal dosing) of DGL for acid reflux or GERD.
DGL appears most promising as a complementary approach—for people seeking to reduce medication use or try natural options, under medical guidance.
It also has some support for ulcer protection, oral mucositis from cancer therapy, and mild IBS symptom relief.

Comparing DGL and Whole Licorice

Feature	DGL	Regular Licorice
Contains Glycyrrhizin?	No	Yes
Risk of High Blood Pressure?	Low	High
Primary Uses	Digestive & mucosal support	Broader use; hormonal, respiratory, gut support
Form for Acid Reflux	Chewable, gummy	Chewable, extract
Safe for Long-Term Use?	Short-term, under supervision	Typically not recommended

Precautions and When to See a Doctor

Do not substitute DGL for prescription medications in severe cases of reflux or GERD without your doctor’s approval.
Consult a physician if you experience new, severe, or worsening symptoms—such as trouble swallowing, chest pain, weight loss, or gastrointestinal bleeding.
DGL should not be used as a diagnosis or cure for underlying serious digestive diseases.
If you are considering DGL and take prescription medications, check for possible interactions.

Frequently Asked Questions (FAQs)

What is the recommended dose and how should I take DGL for acid reflux?

Most studies and expert guidelines suggest chewable DGL tablets or gummies—typically 1–2 tablets (as directed on the label), 20 minutes before meals, to benefit esophageal lining.

How long should I use DGL for?

A typical course lasts 2–4 months, followed by a break to assess for improvement. Consult your healthcare provider for long-term use or repeated courses.

Is DGL safe?

DGL is much safer than whole licorice due to glycyrrhizin removal, but rare side effects or interactions are possible. Pregnant or breastfeeding women and those with chronic conditions should seek medical advice before supplementing.

Will DGL cure my acid reflux?

No supplement is a guaranteed cure for acid reflux. DGL may relieve symptoms in some people but works best as a complementary therapy alongside diet, medication, or medical advice as needed.

Are there people who shouldn’t use DGL?

Yes. Pregnant or breastfeeding individuals, people with hormone-sensitive conditions, or those with liver/kidney dysfunction should not use DGL without consulting a healthcare professional.

Can I take DGL with my prescription medication?

Always discuss new supplements with your doctor because DGL may interact with certain medications.

Conclusion: Is DGL Worth Trying for Acid Reflux?

DGL (deglycyrrhizinated licorice) is a promising natural option for symptomatic acid reflux and mild digestive irritation, particularly for those who want to avoid over-the-counter or prescription acid reducers long-term. It works by strengthening and protecting the mucous lining of the esophagus and stomach, rather than by reducing acid production directly. However, clinical evidence remains limited and it should be used as an adjunct, not a substitute, for established medical therapies. If you are considering DGL, talk with your healthcare provider to determine if this supplement can support your digestive health goals.

References

Author

medha deb

Medha Deb is an editor with a master's degree in Applied Linguistics from the University of Hyderabad. She believes that her qualification has helped her develop a deep understanding of language and its application in various contexts.

Read full bio of medha deb