20 Fast Remedies To Get Rid Of Cold Sores Overnight
Simple herbal solutions calm painful mouth blisters and encourage skin renewal.

Cold sores, often called fever blisters, are common and painful lesions caused by the herpes simplex virus (HSV-1). They usually appear around the mouth or lips and can be both unsightly and uncomfortable. While cold sores often clear up on their own within one to two weeks, there are several remedies and treatments that can help speed up healing and minimize discomfort. This comprehensive guide covers 20 home remedies, over-the-counter options, medical treatments, and answers to frequently asked questions to help you find fast relief.
What Are Cold Sores?
Cold sores are small, fluid-filled blisters that typically develop on or around the lips. They start with a tingling or burning sensation, then evolve into painful bumps that crust over as they heal. The primary cause is the herpes simplex virus type 1 (HSV-1), though they can occasionally stem from HSV-2. Triggers include stress, exhaustion, sun exposure, hormonal changes, and compromised immunity.
Why Fast Treatment Matters
Treating a cold sore at the earliest sign—often the telltale tingling or burning—can help reduce its duration and severity. Quick intervention may make the difference between a minor blemish and a prolonged, painful flare.
Home Remedies For Cold Sores: Natural Options For Relief
If you want to get rid of a cold sore overnight or speed up healing naturally, consider these expert-backed home remedies. While results vary, many people find relief with these treatments. Consult a healthcare provider for severe or frequent outbreaks.
1. Tea Tree Oil
- Properties: Antiviral, antiseptic, and anti-inflammatory.
- Application: Dilute a drop or two of tea tree oil with a carrier oil. Use a cotton swab to dab directly on the sore several times a day and before bed.
- Note: Avoid ingesting; use only topically.
2. Ice Cubes
- Effect: Reduces swelling and soothes itching.
- Application: Place an ice cube or cold pack on the sore for 10-15 minutes. Repeat several times a day.
- Note: Do not scratch or pick at the sore.
3. Lemon Balm Extract
- Properties: Mild antiviral and soothing effects.
- Application: Apply lemon balm ointment or tea infusion with a cotton swab to the sore 3-4 times daily.
4. Honey
- Effect: Promotes healing and can reduce irritation due to its antibacterial and antiviral properties.
- Application: Dab a small amount of raw honey onto the sore with a clean applicator or fingertip. Repeat a few times a day.
5. Licorice Root
- Properties: Glycyrrhizic acid in licorice may help suppress viral activity and speed healing.
- Application: Mix licorice powder with petroleum jelly and apply as a topical balm up to three times daily.
6. Witch Hazel
- Effect: Natural astringent that may reduce inflammation and dry out sores.
- Application: Soak a cotton pad with witch hazel and gently dab on the sore 2-3 times a day.
7. Apple Cider Vinegar
- Properties: Antimicrobial properties may help fight infection.
- Application: Dilute with equal parts water. Gently dab with a cotton swab 1-2 times daily; discontinue if irritation occurs.
8. Garlic
- Effect: Natural antimicrobial qualities may aid healing.
- Application: Crush a garlic clove, place the juice on the sore for a few minutes, then gently wipe off. Repeat twice daily, avoiding prolonged contact with skin.
9. Echinacea Tea
- Properties: Immune-boosting herb that may reduce the frequency of outbreaks.
- Application: Drink Echinacea tea 1-2 times daily when you feel a cold sore coming on.
10. Baking Soda Paste
- Effect: May dry out cold sores and reduce irritation.
- Application: Make a thick paste with baking soda and water. Apply gently to the sore, let it sit for a few minutes, then rinse off.
11. Salt Water Rinse
- Effect: Cleanses and may promote faster healing.
- Application: Dissolve 1 teaspoon of salt in a glass of warm water. Swish gently in the mouth if a sore is present inside.
12. Peppermint Oil
- Properties: Potential antiviral effects.
- Application: Dilute with a carrier oil and use a cotton swab to apply a thin layer 2-3 times a day.
13. Milk Compress
- Effect: Contains immunoglobulins that may help fight the virus and soothes skin.
- Application: Soak a cotton ball in cold milk and apply to the sore for a few minutes. Repeat every two hours.
14. Cornstarch Paste
- Effect: Soothes itching and helps dry out the sore.
- Application: Mix cornstarch with a little water to make a thick paste. Apply and leave on for 10-15 minutes before rinsing off.
15. Aloe Vera Gel
- Properties: Cooling, soothing, and antiviral.
- Application: Apply aloe vera gel with a cotton swab directly onto the sore. Let it dry and repeat 2-3 times daily.
16. Vitamin E
- Effect: Reduces inflammation and promotes healing.
- Application: Prick a vitamin E capsule and apply the oil to the sore with a cotton swab. You can also increase intake of vitamin E-rich foods.
17. Vitamin C
- Effect: Supports immune function and may speed up healing.
- Application: Apply vitamin C-rich serums to the sore or simply increase consumption of vitamin C through diet or supplements.
18. Vanilla Extract
- Effect: Alcohol content may act as an antiviral and dry out sores.
- Application: Dip a cotton swab in pure vanilla extract and dab gently onto the sore four times a day.
19. Zinc Supplementation
- Properties: May support the immune system and thwart viral replication.
- Application: Take zinc supplements as directed, or apply zinc oxide cream topically on the sore.
20. Lysine (Oral Supplement Or Cream)
- Effect: May help manage symptoms and reduce outbreak frequency, though evidence for HSV prevention is limited.
- Application: Use lysine cream directly on the sore or take oral supplements as per product instructions.
Over-The-Counter (OTC) And Prescription Treatment Options
If home remedies are not providing sufficient relief, consider the following medications, which are commonly recommended by healthcare professionals for rapid healing:
- Docosanol (Abreva): An FDA-approved topical cream most effective when applied during the tingling (prodrome) stage.
- Acyclovir (Zovirax): Available as topical cream or oral tablets that directly target HSV replication.
- Famciclovir (Famvir) & Valacyclovir (Valtrex): Prescription oral antivirals that may shorten outbreak duration when taken early.
- Penciclovir (Denavir): Prescription cream applied several times a day to the sore.
Notes on OTC and Medical Treatment
- Medications work best when started at the first sign of a cold sore.
- Pills generally work better than creams in severe cases.
- For extreme pain or very frequent outbreaks, consult your healthcare provider about the best regimen for you.
Alternative Herbal And Supplement Remedies
- Sage and Rhubarb Cream: Herbal combination that may match the effectiveness of standard antiviral creams. Use as directed for topical application.
- Echinacea: May help boost immunity. Drink as a tea or take as a supplement—but always consult with a professional first.
Cold Sore Prevention Tips
Preventing recurrence is crucial if you are prone to cold sores. Consider these practical steps:
- Maintain good immunity with a balanced diet, sufficient sleep, regular exercise, and stress management.
- Avoid triggers, such as excessive sun exposure (use lip balm with SPF), emotional stress, and fatigue.
- Do not share personal items such as lip balm, towels, or utensils during an outbreak.
- Practice frequent handwashing and avoid touching your face.
- Replace toothbrushes after an outbreak to minimize viral spread.
Frequently Asked Questions About Cold Sores
Can you really get rid of a cold sore overnight?
No remedy or treatment can completely eliminate a cold sore overnight. However, starting treatment promptly at the first sign can drastically reduce healing time, shrinking the duration from up to two weeks to a few days.
What is the fastest over-the-counter remedy?
Abreva (docosanol) is FDA-approved and considered one of the fastest OTC options, particularly if applied during the initial tingling phase.
Which home remedies work quickly?
Tea tree oil, aloe vera, raw honey, and lysine are among the speediest home options when started promptly, though results can vary from person to person.
Should I use toothpaste or alcohol to dry out a cold sore?
No. Both toothpaste and alcohol can irritate the skin and potentially prolong the healing process instead of helping it.
How can I prevent cold sores from returning?
Identify your individual triggers (such as sunlight, stress, or hormonal changes) and take proactive steps to avoid them. A strong immune system is your best defense against recurrences.
Cold Sore Vs. Pimple: How To Tell The Difference
Feature | Cold Sore | Pimple |
---|---|---|
Appearance | Cluster of fluid-filled blisters, often on/near lips | Single red bump; may have a white head |
Onset | Itchy, tingling or burning initially; blisters emerge | No warning; bump appears and may grow |
Location | Lip borders, mouth, nose | Anywhere on the face or body |
Cause | Viral infection (HSV-1) | Clogged pore (oil, dead skin, bacteria) |
Pain | Often painful and sensitive | May be tender, less likely to burn/tingle |
When To See A Doctor
- If sores are extremely painful, large, or recurrent
- If you experience frequent outbreaks (more than 4-5 times a year)
- If the sore does not heal within two weeks
- If you have a weakened immune system or are pregnant
- If you have eye symptoms, such as redness, pain, or vision changes
Summary: Key Takeaways For Fast Cold Sore Relief
- Start treatment at the earliest sign—usually the tingling or burning phase.
- Choose a blend of home remedies (like tea tree oil, aloe vera, and honey) and proven antiviral creams or medications.
- Consistent hygiene and preventative care can minimize outbreaks.
- Consult a healthcare provider for persistent, severe, or frequently recurring cold sores.
References
- https://www.pomdental.com/whats-the-fastest-way-to-heal-a-cold-sore-while-you-sleep/
- https://www.stylecraze.com/articles/ways-to-get-rid-of-a-cold-sore-overnight/
- https://barriedentist.ca/big-mouth-blog/general-dental-articles/natural-remedies-canker-cold-sores/%20
- https://www.elle.com/uk/beauty/skin/a41570/how-to-get-rid-of-cold-sore/
- https://www.stylecraze.com/author/sanchari_bhattacharya/
Read full bio of medha deb