Xeomin: The ‘Naked Botox’ Explained—Benefits, Differences, and What to Know

Discover Xeomin, the purified alternative to Botox: how it works, key benefits, differences, and what to expect.

By Sneha Tete, Integrated MA, Certified Relationship Coach

Created on Oct 2, 2025

Discover Xeomin, the purified alternative to Botox: how it works, key benefits, differences, and what to expect.

What Is Xeomin? Understanding the Latest Injectable for Wrinkles

If you’re curious about Xeomin, the buzz-worthy injectable making waves in the beauty industry, you’re not alone. Dubbed the “naked Botox,” Xeomin has quickly risen in popularity for those seeking a wrinkle-smoothing solution that preserves natural expression. But what exactly is Xeomin, how does it compare to Botox, and why are so many people opting for it? This guide will walk you through everything you need to know—from its science-backed advantages and cosmetic uses to what to expect from treatment and safety details.

Xeomin vs. Botox: What’s the Key Difference?

Xeomin and Botox both fall into the category of neuromodulators—injectables that relax targeted facial muscles to soften or erase fine lines and wrinkles. At their core, each contains botulinum toxin type A, a substance that works by blocking nerve signals to muscles, causing them to relax and the skin above to smooth out. However, their similarities largely end there. Let’s break down what sets them apart:

Feature	Xeomin	Botox
Main Ingredient	Botulinum toxin type A (incobotulinumtoxinA), purified, protein-free	Botulinum toxin type A (onabotulinumtoxinA), includes accessory proteins
Formulation	“Naked” neurotoxin—no added complexing proteins or preservatives	Contains additional accessory proteins as stabilizers
FDA Approval	Frown lines (glabellar lines), chronic drooling (children & adults), other medical uses	Frown lines, forehead lines, crow’s feet, various medical conditions
Common Off-Label Uses	Forehead lines, crow’s feet, TMJ, teeth grinding, hyperhidrosis	Same as listed, plus broad cosmetic use
Duration of Results	Typically 3–6 months	Typically 3–4 months
Antibody Resistance Potential	Lower (due to pure formula)	Higher (accessory proteins may trigger antibodies over time)

Xeomin’s purified, protein-free formula means it contains only the active neurotoxin, with no extra complexing proteins or preservatives. This is why it’s often called the “naked injectable.”
Botox includes accessory proteins, which help stabilize the neurotoxin but may increase the potential for the body to develop resistance over time.
Both are FDA-approved for frown lines and various medical conditions, but Xeomin is uniquely approved for treating chronic drooling.

The Science Behind Xeomin’s ‘Naked’ Formula

Developed by Merz Pharmaceuticals, Xeomin’s standout feature is its highly purified manufacturing process. Using advanced filtration technology, only the 150 kD core botulinum neurotoxin remains—the ‘business end’ of the molecule that actually blocks muscle contraction.

Xeomin’s “naked” nickname comes from its lack of added proteins, stabilizers, or preservatives.
No refrigeration required for stability: Xeomin remains shelf-stable for up to four years at room temperature, unlike some neurotoxins that need the cold chain.

What does this mean practically?

By eliminating accessory proteins, Xeomin may reduce the risk of your body building immune resistance to treatment over time. Many experts believe this leads to longer-term effectiveness, especially for those who require repeated treatments.
Research shows the purified neurotoxin is still effective at relaxing muscles and smoothing wrinkles—proving that the added proteins in Botox aren’t actually necessary for wrinkle reduction.

How Does Xeomin Work to Smooth Wrinkles?

Xeomin works by temporarily blocking nerve signals to targeted facial muscles responsible for expression lines. This process:

Reduces muscle contractions
Prevents wrinkle formation or deepening
Allows skin to regenerate and look smoother over time

You’ll typically notice results starting within 3–5 days after injection, with maximum effect reached in about 1–2 weeks. The results generally last between 3–6 months, depending on treatment area, metabolism, and muscle strength.

What Areas Can Xeomin Treat?

While FDA-approved primarily for glabellar lines (those vertical lines between your eyebrows), Xeomin has several off-label uses in cosmetic medicine, often determined by the skill and experience of your provider. Popular treatment areas include:

Glabellar lines (“11” lines/frown lines)
Forehead wrinkles
Crow’s feet (outer corners of the eyes)
Jaw tension and TMJ symptoms
Teeth grinding (bruxism)
Excessive sweating (hyperhidrosis)
Chin dimpling
Vertical lip lines or “smoker’s lines”

Additionally, Xeomin is FDA-approved to treat certain medical conditions, including chronic sialorrhea (drooling) in both adults and children—a feature that’s unique in the neurotoxin treatment landscape.

The Benefits of Xeomin: Natural-Looking Results and More

So why would someone choose Xeomin over Botox or other injectables? Patients and practitioners frequently cite these notable benefits:

Highly purified, additive-free formula: Less risk of immune resistance, lower potential for allergic reactions, and minimal unnecessary exposure for your body.
Natural-looking results: Xeomin allows subtle muscle movement, so you’re less prone to the “frozen” or overdone look and more likely to retain natural facial expressions.
Effective, long-lasting results: Most people see wrinkle reduction lasting three to six months. Some report slightly longer duration than Botox.
Well-tolerated even during repeated treatments: Lower risk of reduced effectiveness compared to protein-containing competitors.
Flexibility for a range of uses: Not just for frown lines—Xeomin can address forehead creases, crow’s feet, jaw issues, and more, depending on the practitioner’s expertise.

Who Makes a Good Candidate for Xeomin?

Xeomin may be right for you if you:

Seek mild-to-moderate improvement in facial wrinkles with minimal risk of a “plastic” appearance
Have shown signs of resistance to Botox or other neurotoxins
Prefer a more pure, additive-free cosmetic injectable
Wish for a quick, minimally invasive procedure with virtually no downtime
Are otherwise healthy and not pregnant or breastfeeding

Ultimately, the suitability of Xeomin versus other options like Botox or Dysport should be determined in consultation with a qualified cosmetic or medical professional, who can assess your medical history, goals, and preferences.

How Is Xeomin Injected and What’s the Treatment Like?

The Xeomin procedure is quick, most often taking only 10–20 minutes in the office. Here’s what you can typically expect:

Your provider will assess your facial anatomy and map out targeted injection points
A very fine needle is used for a series of shallow injections in the area of concern
Discomfort is minimal, often described as a quick pinch
No anesthetic is required, and you can return to most normal activities right away
Bruising, swelling, or redness at the injection site are common but usually fade within a few days

Risks, Side Effects, and Safety Profile

Xeomin shares a similar safety profile with other botulinum toxin-based injectables. While side effects are rare and usually temporary, it’s important to be aware of potential risks:

Common side effects: Mild redness, swelling, bruising, tenderness at the injection site; headaches; minor muscle weakness or drooping
Rare but serious risks: Allergic reaction, infection, spreading of toxin effects beyond site of treatment (may affect swallowing or breathing, especially when used for medical conditions)
Who should not use? Individuals with allergies to botulinum toxin, certain neurological disorders, or those who are pregnant or breastfeeding should avoid use unless cleared by a doctor

Always choose a board-certified provider experienced in neuromodulator injections to lower risks and ensure optimal results.

Xeomin vs. Other Wrinkle Treatments: Is It Better?

The “best” injectable depends on your goals, skin type, and treatment history. Some key advantages of Xeomin over competitors:

No accessory proteins: Lower risk of resistance, especially if you’ve noticed decreased effects with Botox
Natural feel and movement: Ideal for those who want results without obvious stiffness
Long-term suitability: Better option for individuals planning frequent or ongoing treatments

However, if you are happy with your Botox results and haven’t experienced issues like resistance, there’s not always a pressing need to switch. Xeomin often appeals most to those new to neuromodulators, those wanting “refreshed not frozen,” or those seeking alternatives after plateauing with other products.

Frequently Asked Questions About Xeomin

Is Xeomin as effective as Botox?

Clinical studies and expert consensus show Xeomin is equally effective to Botox at reducing dynamic wrinkles, with most people achieving comparable results and duration.

When will I see results from Xeomin?

You’ll typically notice the effects begin 3–5 days after your treatment, with maximum smoothing around 1–2 weeks.

How long do Xeomin results last?

Results usually last 3–6 months, depending on your muscle movement, metabolism, and area treated. For some, the pure formula can yield longer-lasting results.

What makes Xeomin “naked” or purer than Botox?

Xeomin contains only the core neurotoxin, with no extra accessory proteins or unnecessary additives often found in other injectables. This pure formulation may reduce allergic reactions and lower the chance of your body developing resistance over time.

Can you develop resistance to Xeomin?

Resistance is much less likely due to the absence of stabilizing proteins that trigger the immune system. That said, resistance is possible, though rare, with any neuromodulator.

How much does Xeomin cost?

Costs vary based on practice location, treatment area, and the number of units used, but prices usually range from $10–$16 per unit, similar to Botox. Always opt for an experienced provider for the safest and best results.

Is Xeomin safe for everyone?

Most adults seeking cosmetic treatment for wrinkles can safely use Xeomin, but it’s not recommended for those who are pregnant, breastfeeding, or have certain neuromuscular conditions. Always disclose your medical history during your consultation.

Can Xeomin be combined with other cosmetic treatments?

Yes, Xeomin is often paired with dermal fillers, lasers, or skincare routines to create a comprehensive facial rejuvenation plan. Combination approaches should always be tailored by your provider.

Expert Tips for Choosing Between Xeomin and Botox

If you want the safest formula with the lowest chance of resistance, Xeomin’s pure approach might be ideal
If you’ve never tried wrinkle relaxers, starting with Xeomin offers peace of mind for first-timers seeking subtle, natural improvements
Speak openly with your provider about your complete medical history, previous injectable experiences, and cosmetic goals
Choose a provider with significant experience in both Xeomin and Botox for individualized guidance and optimal technique

Summary: Is Xeomin Right for You?

Xeomin stands apart as a next-generation neuromodulator, offering purified wrinkle-smoothing results for those seeking a refreshed but authentic look. With a protein-free formulation, reduced risk of antibody resistance, and natural-feeling outcomes, it’s no wonder more people are asking about the “naked Botox.” Whether you’re new to injectables or hunting for a more advanced solution, Xeomin may be the modern, minimally invasive choice for longer-lasting expression confidence. For any cosmetic procedure, always consult a board-certified specialist to determine what works best for your individual needs and facial anatomy.

References

Author

Sneha TeteBeauty & Lifestyle Writer

Sneha is a relationships and lifestyle writer with a strong foundation in applied linguistics and certified training in relationship coaching. She brings over five years of writing experience to thebridalbox, crafting thoughtful, research-driven content that empowers readers to build healthier relationships, boost emotional well-being, and embrace holistic living.

Read full bio of Sneha Tete