Types of Botox: Comparing Botox, Xeomin, Dysport, Jeuveau, and Daxxify
Explore the differences between Botox, Dysport, Xeomin, Jeuveau, and Daxxify, their effectiveness, uses, and tips for selecting the right neurotoxin for you.
Botulinum toxin injectables have revolutionized the way we approach anti-aging. Botox may be the classic name everyone knows, but in the world of wrinkle-smoothing and facial rejuvenation, there are now several options: Botox, Dysport, Xeomin, Jeuveau, and Daxxify. Each serves the same fundamental purpose—temporarily reducing muscle movement to smooth fine lines—but their differences are worth examining to make the most informed decision for your cosmetic goals.
What Are the Types of Neurotoxins?
All these injectables are classified as botulinum toxin type A products, though they are manufactured slightly differently and can vary in duration, diffusion, and effect. Here’s a breakdown of the most popular options:
- Botox (onabotulinumtoxinA)
- Dysport (abobotulinumtoxinA)
- Xeomin (incobotulinumtoxinA)
- Jeuveau (prabotulinumtoxinA-xvfs)
- Daxxify (daxibotulinumtoxinA-lanm)
Botox (onabotulinumtoxinA)
Botox is the brand name most familiar to the public and has the longest-standing safety profile in both medical and cosmetic applications. First approved by the FDA in 1989 for treating certain eye disorders, it received official cosmetic approval in 2002 for frown lines. Today, Botox holds the most FDA-approved uses for both cosmetic (like smoothing forehead lines, crow’s feet, glabellar lines) and medical issues (such as treating migraines, excessive sweating, and muscle spasms).
- Onset: Effects are typically visible within a few days, with full results at about two weeks.
- Duration: Results last around three to six months. Some individuals—especially those who are very active—may notice shorter durations due to faster metabolism of the toxin.
- Popularity: Known as the ‘Kleenex’ of injectables, Botox is widely requested by name and is seen as a reliable, consistent option.
- Indications: Approved to treat forehead lines, crow’s feet, glabellar lines, and more. Off-label uses include jawline slimming, chin wrinkles, neck bands, lip lines, and brow lifting.
Its popularity also means it is the baseline against which all other neurotoxins are measured, and most injectors are well-versed in its use.
Dysport (abobotulinumtoxinA)
Dysport is another widely used neurotoxin injectable that shares the same active ingredient as Botox. Approved by the FDA for aesthetic use in the treatment of moderate to severe glabellar lines (frown lines between the eyebrows), it is often chosen for its unique formulation:
- Diffusion: Dysport tends to spread more easily than Botox, making it desirable for treating broader areas such as the forehead.
- Onset: Effects may be noticeable within 2-3 days, which can be slightly quicker than Botox for some people.
- Duration: Results last about 3-5 months for most patients.
- FDA Approvals: Cosmetic approval for glabellar lines; also used for certain muscle spasticity disorders.
- Cost: Dysport may appear less expensive, but because it is less concentrated and spreads more, more units may be needed to achieve equivalent results to Botox.
Dysport’s tendency to diffuse farther can be both a benefit and a challenge: it’s great for large areas with naturally broad muscle movement, but precision may be more difficult in smaller, focused areas.
Xeomin (incobotulinumtoxinA)
Xeomin is unique among neurotoxins because it is considered a ‘naked’ injectable. This means it lacks complexing proteins—proteins added in other formulations to stabilize the toxin.
What others are reading
- Purity: Free of accessory proteins, reducing the risk of your body developing antibodies and becoming resistant to treatment.
- Use Cases: FDA-approved for glabellar lines, with off-label uses similar to other toxins. Also approved for several medical conditions, such as chronic sialorrhea (drooling).
- Onset: Effects usually appear within 3-4 days.
- Duration: Results typically last 3-4 months.
In clinical settings, Xeomin is often recommended for people who have used other toxins for years with diminishing results, suggesting the absence of stabilizing proteins may help in cases of resistance.
Jeuveau (prabotulinumtoxinA-xvfs)
The newest of the neurotoxins discussed here, Jeuveau was designed exclusively for cosmetic applications. It is marketed as “Newtox,” catering to a younger demographic eager to maintain smooth skin or start preventative treatments.
- Indications: Specifically FDA-approved for the temporary improvement of moderate to severe glabellar lines.
- Onset and Duration: Similar timeline to Botox; full results in 1-2 weeks, lasting about 3-4 months.
- Positioning: Slightly lower price point and contemporary branding make it appealing for new users or those on a budget.
It is formulated very similarly to Botox, so doctors and patients may use them interchangeably depending on specific needs or cost considerations.
Daxxify (daxibotulinumtoxinA-lanm)
Daxxify is the latest addition to the neurotoxin market, earning its buzz for a significantly longer duration of effect. It is distinguished by its peptide-powered formula, made to last longer than other toxin products.
- Duration: Daxxify has demonstrated effects for up to six months—sometimes even longer in clinical trials.
- Onset: Effects appear within days to a week, similar to other neurotoxins.
- Indications: FDA-approved for glabellar lines, with further cosmetic uses expected as research continues.
- Unique Feature: Uses a different peptide stabilizer than the human or animal-derived proteins seen in other injectables, which may decrease the body’s likelihood of developing resistance.
Daxxify’s longevity makes it an appealing option for those seeking less frequent treatments, though it may come at a higher cost. Its novelty means experience among injectors is still growing.
How Botulinum Toxin Works for Wrinkles
All five neurotoxins are derived from Clostridium botulinum bacteria and work by temporarily blocking nerve signals to targeted muscles. By weakening specific muscle contractions, the appearance of dynamic wrinkles—those formed by facial movement—significantly decreases. The injection procedure is minimally invasive and downtime is minimal, with most patients returning to normal activity right after.
Common Treatment Areas
- Forehead lines
- Glabellar lines (“elevens”) between the eyebrows
- Crow’s feet at the corners of the eyes
- Bunny lines on the bridge of the nose
- Chin dimples and lines
- Jawline and neck bands
- Lip lines and “lip flip” procedures
Results and side effects are generally similar among the various formulations, with subtle differences based on individual response and injector preference.
Comparing the Types: Pros and Cons
| Product | Main Feature | FDA Approvals | Onset | Duration | Best For |
|---|---|---|---|---|---|
| Botox | Longest track record, most versatile | Many cosmetic & medical | 3–7 days | 3–6 months | Broad use, reliable results |
| Dysport | Spreads more easily | Glabellar lines, spasticity | 2–3 days | 3–5 months | Larger areas (e.g., forehead) |
| Xeomin | No accessory proteins | Glabellar lines, drooling | 3–4 days | 3–4 months | Reducing risk of resistance |
| Jeuveau | Budge-friendly, cosmetic focus | Glabellar lines | 3–7 days | 3–4 months | First-timers, price-conscious |
| Daxxify | Longest-lasting | Glabellar lines | Few days | ~6 months | Low maintenance, fewer visits |
Can You Mix and Match Brands?
While manufacturers recommend sticking to one brand per treatment session, in real practice, experienced injectors often mix neurotoxins to target different areas based on each product’s unique strengths. For example, a provider might use Dysport for broad forehead areas and switch to Botox or Xeomin for precise work around the mouth or eyes. This specialized approach can optimize both longevity and quality of results, especially in patients who have used neurotoxins long-term or whose bodies metabolize certain brands faster. Some providers also alternate brands over time to decrease the chance of developing resistance.
Factors to Consider When Choosing Your Neurotoxin
- Your aesthetic goals: Are you addressing deep wrinkles, mild lines, or seeking prevention?
- Your anatomy: Some neurotoxins spread more, so facial structure and targeted muscles matter.
- Duration preferences: If you prefer fewer appointments, the longer-acting Daxxify may appeal.
- Cost: Pricing per unit can vary. Units needed differ by product and treatment area.
- History of response: If you’ve developed partial resistance or reduced response, trying a different brand (such as Xeomin for those sensitive to accessory proteins) may restore efficacy.
- Your injector’s expertise: The skill and technique of your provider are paramount—injector experience often matters more than the product itself.
Safety, Side Effects, and Longevity
All neurotoxin injectables share a strong safety record when performed by licensed and skilled professionals. Side effects are typically mild and temporary and can include bruising, swelling at the injection site, headache, or mild drooping if the injection point is too close to certain muscles. Long-term, repeated use is common, though an exceedingly rare risk of toxin resistance exists, typically in those with frequent, high-dose, or long-term use.
Frequently Asked Questions (FAQs)
Which brand lasts the longest?
Daxxify currently boasts the longest duration, with smooth results lasting up to six months or longer for some users. Botox’s effects usually last 3–6 months, with Dysport, Xeomin, and Jeuveau averaging 3–5 months.
Can I switch from one neurotoxin brand to another?
Yes. Many patients switch between brands based on response, doctor recommendation, or availability. Mixing injectables in one session is less common, but skilled providers may tailor the approach for optimal results.
What’s the difference between botulinum toxin type A and B?
Type A (the form found in all listed brands) is used for cosmetic wrinkle reduction. Type B is mainly used for specific medical conditions, such as dystonia, and not for cosmetic purposes.
Why is Botox often used as a generic term for these injectables?
Botox was the first botulinum toxin approved for cosmetic use and became a household name; as a result, many refer to all similar treatments as “Botox,” though each brand has unique characteristics.
How can I maximize my results and make injections last longer?
- Follow your injector’s aftercare advice to minimize swelling and ensure proper placement.
- Avoid strenuous exercise for 24 hours post-injection.
- Consider rotating brands or treatment areas if you experience reduced efficacy over time.
- Choose a board-certified dermatologist or plastic surgeon with significant experience in injectables.
Final Thoughts: Botox and Beyond
The rise in neurotoxin injectables has provided more options than ever before to preserve a smoother, younger-looking complexion. With Botox, Dysport, Xeomin, Jeuveau, and Daxxify each offering specific advantages, the best choice ultimately depends on your personal goals, medical history, and provider’s expertise. Speaking openly with a well-qualified injector about all available options ensures a tailored approach — and the best possible results for your face.
References
- https://www.cosmopolitan.com/style-beauty/beauty/a64442908/types-of-botox/
- https://www.goodrx.com/botox/alternatives
- https://cosmoderma.org/where-and-how-to-use-botulinum-toxin-on-the-face-and-neck-indications-and-techniques/
- https://www.aafp.org/pubs/afp/issues/2014/0801/p168.html
- https://www.cosmopolitan.com/style-beauty/beauty/a36462846/botox-cost-guide/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6489637/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3586120/
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